University of Sharjah C/o Dr. Mohamed Al Hemairy MAlhemairy@sharjah.ac.ae
发明人:
Taleb H. Altel,Raafat A El-Awady,Srinivasulu Vunnam,Cijo George Vazhappilly,Hany A. Omar
申请号：
US15935155
公开号：
US20190292204A1
申请日:
2018.03.26
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Novel heterocyclic systems are herein disclosed, which possess many biological activities, including but not limited to anticancer activity. The disclosed compounds are useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for their preparations and methods for their pharmaceutical applications, for example, as anticancer agents. These compounds were found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compounds also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, these novel compounds were able to target multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.
