The invention provides a articular cartilage imaging composition which can clearly distinguish and visualize the normal and abnormal denatured parts of articular cartilage. The articular cartilage imaging composition contains positive charged molecules, which are labeled with marker molecules.本發明提供能够將關節軟骨的正常部位和非正常的變性部位明確區別並可視化的關節軟骨成像組合物。關節軟骨成像組合物含有陽性帶電分子,陽性帶電分子用標記分子進行了標記。