Constantin G. Ioannides;Martin L. Campbell;Catherine A. O'Brian;George E. Peoples
发明人:
Constantin G. Ioannides,Martin L. Campbell,Catherine A. O'Brian,George E. Peoples,Catherine A. OBrian
申请号：
US10507009
公开号：
US08802618B2
申请日:
2003.03.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens.
