Provided is an aminopropylidene derivative having excellent antagonistic activity on histamine receptor, which is a compound useful as an effective ingredient of a pharmaceutical composition, especially as anti-histamine drugs. The aminopropylidene derivatives according to this invention have a strong antagonistic activity on histamine receptor. Further, the compounds according to this invention exhibit a low brain transfer in a brain receptor binding test of mice oral administration, thus have good properties in the view of decreasing central nervous side effect, such as decreased sleepiness and the like. The compounds according to this invention are useful as an effective ingredient of pharmaceutical composition such as novel anti-histamine drug and the like, with a decreased central nervous side effect such as sleepiness and the like.本發明提供一種具有優良組織胺受體拮抗作用的胺基亞丙基衍生物，係用於做為醫藥組成物，特別是抗組織胺藥等之有效成分的化合物。本發明之胺基亞丙基衍生物具有強力的組織胺受體拮抗活性。再者，本發明化合物在小鼠經口給藥的腦內受體結合試驗中，表現低的腦內移行性，因此在減輕睡意等中樞性副作用之點而言，具有理想的特性。因此，本發明之胺基亞丙基衍生物做為睡意等中樞性副作用少的新穎抗組織胺藥等醫藥組成物的有效成分非常有用。
