吡咯并嘧啶化合物及其用途农业专利-农业学术服务平台

发明人:: BESONG, GILBERT,毕宋　吉伯特,畢宋　吉伯特,BRAIN, CHRISTOPHER THOMAS,布雷恩　克里斯多弗　汤玛斯,布雷恩　克里斯多弗　湯瑪斯,BROOKS, CLINTON A.,布鲁克斯　柯林顿Ａ,布魯克斯　柯林頓Ａ,CONGREVE, MILES STUART,康古利夫　麦尔斯　史都华,康古利夫　麥爾斯　史都華,DAGOSTIN, CLAUDIO,达勾斯丁　克劳迪欧,毕宋吉伯特,畢宋吉伯特,布雷恩克里斯多弗汤玛斯,布雷恩克里斯多弗湯瑪斯,布鲁克斯柯林顿A,布魯克斯柯林頓A,康古利夫麦尔斯史都华,康古利夫麥爾斯史都華,达勾斯丁克劳迪欧

摘要：: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.所揭示之化合物係關於蛋白質激酶有關聯病症之治療藥品與療法。亦有需要可用於治療或預防或改善癌症、移植排斥及自身免疫疾病之一或多種病徵之化合物。再者，有需要關於使用本文中所提供之化合物以調制蛋白質激酶活性之方法，該激酶譬如CDK1、CDK2、CDK4、CDK5、CDK6、CDK7、CDK8及CDK9。