THE SCHEPENS EYE RESEARCH INSTITUTE, INC.;MASSACHUSETTS EYE AND EAR INFIRMARY
发明人:
VANDENBERGHE, LUK H.,MAURER, ANNA CLAIRE
申请号：
CA3061968
公开号：
CA3061968A1
申请日:
2018.05.10
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
This disclosure describes and demonstrates the utility of a particularsequence motif within an Adeno-associated virus(AAV) capsid protein that enables the assembly-activating protein (AAP)-dependence of the AAV to be modified. Thus, this sequencemotif can be use to address and alleviate at least one of the bottlenecksencountered in the production of virus vectors. In particular,this disclosure describes a minimal motif defined through a novel phenotype-to-phylogeny mapping method that can be used to modifythe AAP dependence of a virus.
