PROBLEM TO BE SOLVED: To develop a therapeutic agent under the concept of preventing the occurrence of resistant bacteria in order to completely overcome infection.SOLUTION: A TSST-1 production inhibitor comprises a conditioned medium of Lactobacillus plant lactic acid bacteria or a purified product from the conditioned medium, and also comprises, as a material having TSST-1 production inhibitory activity, a compound that has a molecular weight 100 kDa or more and is mainly composed of polypeptides and lipids.SELECTED DRAWING: None【課題】感染症の完全克服を実現するために、耐性菌を出現させないコンセプトにて治療薬を開発すること。【解決手段】Lactobacillus属の植物乳酸菌の培養上清または該培養上清からの精製物を含有しており、ＴＳＳＴ－１産生阻害活性を有する物質として、分子量１００ｋＤａ以上である、ポリペプチドおよび脂質を主構成成分とする化合物を含んでいるＴＳＳＴ－１産生阻害剤を提供する。【選択図】なし
