A perfusion system that is easy to set-up, use and monitor during a bypass procedure includes at least some disposable components configured to communicate parameters to the perfusion system. An ultrasonic blood level sensor (86) can be used to monitor a blood level or volume within a blood reservoir (82). The blood level sensor may be utilized in an integrated perfusion system in which the disposable components are configured, as noted above, to communicate (90) with the perfusion system.