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(S)-N-(5 - ((R)-2-(2,5-二氟苯基)吡咯烷-1-基) - 吡唑並[1,5-A ]嘧啶-3-基)-3-羥基吡咯烷-1-甲酰胺硫酸氫鹽
专利权人:
Inc.;Array Biopharma
发明人:
Alisha B. ARRIGO,Derrick JUENGST,Khalid SHAH
申请号:
HK18103883.4
公开号:
HK1244483A
申请日:
2018.03.20
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
A novel crystalline form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment of pain, cancer, inflammation, neurodegenerative disease or Trypanosoma cruzi infection are disclosed. In some embodiments, the novel crystalline form comprises a stable polymorph of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate. The present invention is further directed to a process for the preparation of the novel crystalline form.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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