The Trustees of the University of Pennsylvania;Janssen Biotech, Inc.
发明人:
Maria P. Limberis,Anna P. Tretiakova,James M. Wilson,Michael Naso,Joost Kolkman,Robert Friesen,Qiang Wang
申请号：
US15906887
公开号：
US20180243416A1
申请日:
2018.02.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV inverted terminal repeat sequences and at least one nucleic acid sequence encoding four different immunoglobulin regions (a), (b), (c) and (d) is provided. The rAAV-expressed immunoglobulins are useful for providing passive immunization against influenza A and influenza B. Also described herein are compositions containing the rAAV. Methods of vaccinating patients against influenza are provided.
