HILBERT, David M.,SWERS, Jeffrey S.,LAFLEUR, David W.
申请号:
AU2018368431
公开号:
AU2018368431A1
申请日:
2018.11.14
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
Provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and their use in directing immune responses to target cells. The compositions have uses that include treating hyperproliferative disorders such as cancer. The provided methods generally include the use of a CAR cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or redirect CAR cell-mediated immune response