Capsicum compositions comprised of biologically active constituents non-capsaicinoids and capsaicinoids in specific ratio are described for the management of cardiometabolic syndrome and associated risk factors, in a subject, in need thereof. The compositions are comprised of capsicum extract which is prepared by extracting capsicum pods by using suitable polar and non-polar solvents. Capsicum compositions are comprised of non-capsaicinoid components like saponins and polyphenols such as flavonoids, which along with capsaicinoids effectively reduce risk factors of cardiometabolic syndrome and also reduce oxidative stress on vital body organs by reducing inflammatory and/or oxidative markers. The compositions inhibit pancreatic lipase enzyme and enhance lipolysis, when administered in effective amounts to the subjects in need thereof. Capsicum compositions as described herein, are prepared by human intervention and are safe for consumption and effective for management of cardiometabolic syndrome in subject in need thereof.
