Certain embodiments of the present invention provide systems and methods for clinical study notification. Certain embodiments provide a method for clinical study notification. The method includes accessing a pool of potential study participants generated from electronic patient data. The method also includes identifying one or more healthcare providers associated with the pool of potential study participants. The method further includes electronically communicating with the one or more healthcare providers and/or the pool of potential study participants regarding participation in a clinical study. Additionally, the method includes allowing the one or more healthcare providers and/or the pool of potential study participants to join the clinical study.