Substituted Heterocyclic Compounds, modulators of Nuclear Transport； Pharmaceutical Composition and its use for the treatment of a disorder associated with CRM1 activity Disorder, such as cancer, abnormal Tissue Growth, fibrosis, among others.
or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.COMPUESTOS DERIVADOS DE HETEROCICLOS SUSTITUIDOS, MODULADORES DEL TRANSPORTE NUCLEAR (CRM1)； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE； Y SU USO PARA EL TRATAMIENTO DEL CANCER, ENFERMEDADES INFLAMATORIAS, CRECIMIENTO TISULAR ANORMAL, FIBROSIS, ENTRE OTRAS.
