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OPHTHALMIC SOLUTION OF DIFLUPREDNATE
专利权人:
发明人:
Ajay Jaysingh Khopade,Arindam Halder,Ankit Shaileshkumar Shah
申请号:
US15768316
公开号:
US20180311159A1
申请日:
2016.10.15
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides a method of treatment of inflammatory disorder of the eye, said method comprising administering into the eye of a person in need thereof, an aqueous solution comprising difluprednate as the sole active ingredient at a concentration of 0.02% to 0.04% weight by volume in an aqueous vehicle, wherein the solution is free of oil and wherein the solution is administered twice-a-day. The present invention also provides an ophthalmic solution comprising a. therapeutically effective concentration of difluprednate, a crystal growth inhibitor and pharmaceutically acceptable amounts of a solubilizer comprising a mixture of i. quaternary ammonium compound and ii. polyethoxylated castor oil, b. in an aqueous vehicle. wherein the crystal growth inhibitor is polyvinyl alcohol or its derivatives.
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