PROBLEM TO BE SOLVED: To provide compounds and a method for determining the activity, which inhibit formation of advanced glycation end-products (AGEs) due to the glycation of cutaneous proteins, in particular, collagen, accompanying aging.SOLUTION: Compositions including a biflavonoid-rich Garcinia kola extract or fraction are used to inhibit the glycation of proteins, in particular the glycation of skin collagen involved in cutaneous aging. Also provided is a method for determining the activity of compounds for inhibiting the glycation of cutaneous proteins, in particular, the glycation of collagen.【課題】加齢に伴う皮膚蛋白質、特にコラーゲンの糖化による、終末糖化産物（ＡＧＥ）を形成を阻外する、化合物、及び活性を判定する方法の提供。【解決手段】ビフラボノイドを多く含むガルシニア・コラの抽出物又は画分を含む組成物の、タンパク質の糖化、特に、皮膚の加齢に関与する皮膚コラーゲンの糖化を阻害するための使用。同様に、皮膚タンパク質の糖化、特に、コラーゲンの糖化を阻害するための化合物の活性を判定するための方法。【選択図】図５
