ASHLEY SUE MCCARRON,MATTHEW STIRLING,STEPHEN G. STROUD,TODD B. SELLS
申请号：
BR112014004239
公开号：
BR112014004239A2
申请日:
2012.08.23
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract: disclosed are chemical entities which are inhibitors of nedd8-activating enzyme (nae), namely, the compound {(1s, 2s, 4r) -4 - [(6 - {[(1r, 2s) -5- chloro-2-methoxy-2,3-dihydro-1h-inden-1-yl] amino} pyrimidin-4-yl) oxy] -2-hydroxycyciopentyl} methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer. 56 translation of abstract patent summary: "nedd8 activating enzyme inhibitors". chemical entities are disclosed that are inhibitors of nedd8 activating enzyme (nae), i.e. the compound {(1s, 2s, 4r) -4 - [(6 - {[(1r, 2s) -5-chloro-2- methoxy-2,3-dihydro-1h-inden-1-yl] amino} pyrimidin-4-yl) oxy] -2-hydroxycyclopentyl} methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. Methods for using chemical entities to treat disorders such as cancer are also disclosed.abstract: (en)disclosed are chemical entities which are inhibitors of nedd8-activating enzyme (nae), namely, the compound {(1s,2s,4r)-4-[(6-{[(1r,2s)-5-chloro-2-methoxy-2,3-dihydro-1h-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyciopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. also disclosed are methods of using the chemical entities to treat disorders such as cancer. 56 tradução do resumo resumo patente de invenção: "inibidores de enzima ativadora de nedd8". são reveladas entidades químicas que são inibidoras de enzima ativadora de nedd8 (nae), ou seja, o composto {(1s,2s,4r)-4-[(6-{[(1r,2s)-5-cloro-2-metoxi-2,3-di-hidro-1h-inden-1-il]amino}pirimidin-4-il)oxi]-2-hidroxiciclopentil}metil sulfamato e sais farmaceuticamente aceitáveis dos mesmos； formas em estado sólido dos mesmos； e pró-drogas dos mesmos. são ainda revelados métodos para uso das entidades químicas para tratar distúrbios como câncer.
