PROBLEM TO BE SOLVED: To provide fine particles for preparation, capable of masking unpleasant feeling in the oral cavity such as bitterness and numbness feeling when taking a medicament through the oral cavity, and capable of rapidly releasing an active ingredient in the stomach, and to provide the medicament containing the fine particles for the preparation.SOLUTION: The fine particle for the preparation, in one aspect, comprises a core particle containing an acid-addition salt of a basic medicament, and a pharmaceutically acceptable inorganic or organic basic compound, and a water-permeable film formed on the outside of the core particle and containing a water-insoluble polymer, and, when being taken, rapidly releases the medicament in the stomach or in the upper part of the small intestine by the break of the film while suppressing the diffusion and elusion of the basic medicament in the oral cavity. The fine particle for the preparation, in another aspect, comprises a core particle containing an acid-addition salt of a basic medicament, an intermediate film formed on the outside of the core particle, and comprising a water-soluble polymer containing a pharmaceutically acceptable inorganic or organic basic compound, and a water-permeable outermost film formed on the outside of the intermediate film and containing a water-insoluble polymer, and, when being taken, rapidly releases the medicament in the stomach or in the upper part of the small intestine by the break of the outermost film while suppressing the diffusion and elusion of the basic medicament in the oral cavity.COPYRIGHT: (C)2013,JPO&INPIT【課題】製剤を口腔内で服用するとき、苦味や痺れ感などの口腔内の不快感を隠蔽することが可能であって、かつ、胃内で速やかに有効成分を放出することが可能な製剤化用微粒子とそれを含む製剤を提供する。【解決手段】製剤化用微粒子は、1つの局面においては、塩基性薬物の酸付加塩および薬学的に許容される無機または有機塩基性化合物を含んでいるコア粒と、該コア粒の外側に形成された、水不溶性高分子を含んでいる水透過性皮膜からなり、服用時、口腔内で塩基性薬物の拡散溶出は抑制されるが、胃内または小腸上部で皮膜が破れ、速やかに薬物が放出されることを特徴とする。製剤化用微粒子は、別の局面においては、塩基性薬物の酸付加塩を含んでいるコア粒と、該コア粒の外側に形成された、薬学的に許容される無機または有機塩基性化合物を含んでいる水溶性高分子を含んでいる中間皮膜と、該中
