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Methods and compositions for imaging
专利权人:
Edward A. Fisher
发明人:
Edward A. Fisher,Zahi A. Fayad,Kevin J. Williams
申请号:
US10557094
公开号:
US08097283B2
申请日:
2005.01.14
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention is directed to synthetic nanoparticles useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. The synthetic nanoparticles comprise at least one apolipoprotein that is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent linked through a chelator to a component of the nanoparticle, wherein the one metallic or non-metallic contrast agent is present in an amount of between 5% to about 50% (w/w) of the nanoparticle, and the nanoparticle has a diameter of from about 5 nm to about 50 nm. Compositions and kits comprising the synthetic nanoparticles and methods of making and using the same are also provided.
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