THE UNITED STATES OF AMERICA; as represented by the Secretary; Department of Health and Human
发明人:
Amy Hauck Newman,Oluyomi M. Okunola-Bakare,Jianjing Cao
申请号：
US15830244
公开号：
US20180093947A1
申请日:
2017.12.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.
