An information processing system includes a storage, a designation unit, an extraction unit, and an output controller. The storage stores a plurality of element combinations in each of which elements belonging to two or more of a plurality of items concerning a current state of a patient are associated, and explanation information pieces each to be presented to a patient associated with a corresponding one of the element combinations and/or a person relevant to the patient. The designation unit designates, in response to a signal according to a user action, a combination of elements belonging to two or more of the plurality of items. The extraction unit extracts, from the explanation information pieces stored in the storage, an explanation information piece corresponding to the combination designated by the designation unit. The output controller causes an output unit to output the explanation information piece extracted by the extraction unit.
