attenuated respiratory syncytial virus, immunogenic composition, nucleic acid molecule, recombinant cell, method for producing a protective immune response in a patient, and use of an immunologically effective amount of one or more of the following: an attenuated rsv, a population of rsv attenuated and an immunogenic composition.
DANIEL J. DISTEFANO,DAVID L. KRAH,MARY K. YAGODICH,MICHAEL P. CITRON,XIAOPING LIANG
申请号：
BRPI0921424
公开号：
BRPI0921424A2
申请日:
2009.11.03
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention features live, attenuated respiratory syncytial viruses (RSV) useful as vaccines against RSV infection and/or the development of severe RSV-associated illnesses. The disclosed viruses are attenuated to the extent of being nonpathogenic when administered to a subject but substantially retain the antigenic and immunogenic properties of wild-type RSV.
