The present invention provides isolated polypeptides comprising a modified fibronectin fragment that comprises FNIII 10 and optionally further comprising FNIII 9. Also provided are pharmaceutical compositions comprising the polypeptides and methods of making and using the polypeptides.本發明提供多肽,其包含含有FNIII 10的經修飾纖維黏連蛋白片段,且視情況包含FNIII 9。本發明亦提供包含該多肽之醫藥組合物以及製備及使用該多肽之方法。