in vivo imaging agent and method, precursor compound, kit, cassette, radiopharmaceutical composition, and methods for preparing the in vivo imaging agent and for diagnosing a condition
Bo Shan,Dennis O' Shea,Harry John Wadsworth,Joanna Marie Passmore,William John Trigg
申请号：
BRPI0919551
公开号：
BRPI0919551A2
申请日:
2009.10.02
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tissues expressing higher levels of PBR. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. A cassette for the automated synthesis of the in vivo imaging agent is also provided. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.
