In a first aspect, the present invention relates to a vehicle composition, in particular, to a vesicular composition or a particular composition comprising either vesicle forming components or particles, optionally, an active agent associated with the vesicle forming components or particles, and folate receptor alpha. In another aspect, the present invention relates to a delivery system for the transport of components and/or active agents into the cerebrospinal fluid (CSF) and/or brain and/or central nervous system and/or spinal cord comprising vesicles or particles and folate receptor alpha, preferably being located on the outer surface of said vesicles or particles. The present invention relates further to a method for the delivery of components and/or active agents, in particular, of active agents into the CSF and/or brain and/or central nervous system and/or spinal cord as well as for treating of CSF or brain pertaining diseases, disorders or conditions. In particular, the present invention relates to a method for preventing or treating neurological or neurodegenerative diseases, disorders or conditions, comprising administering the delivery systems or vehicle composition according to the present invention.Dans un premier aspect, la présente invention concerne une composition de véhicule, en particulier une composition vésiculaire ou une composition particulaire comprenant des composants formant des vésicules ou des particules, facultativement, un agent actif associé aux composants formant des vésicules ou aux particules, et un récepteur alpha du folate. Dans un autre aspect, la présente invention concerne un système de délivrance pour le transport de composants et/ou dagents actifs dans le liquide céphalorachidien (LCR) et/ou le cerveau et/ou le système nerveux central et/ou la moelle épinière comprenant des vésicules ou des particules et un récepteur alpha du folate, de préférence étant situé sur la surface extérieure desdites vésicules ou desdites particules.
