METHODS AND COMPOSITIONS RELATED TO SOLUBLE MONOCLONAL VARIABLE LYMPHOCYTE RECEPTORS OF DEFINED ANTIGEN SPECIFICITY

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专利权人:

THE UAB RESEARCH FOUNDATION

发明人:

COOPER, MAX D

申请号：

NZ57447307

公开号：

NZ574473A

申请日:

2007.07.27

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

Provided is a method of making a soluble, monoclonal agnathan antigen specific polypeptide comprising a. isolating a cDNA clone encoding an agnathan antigen specific polypeptide, wherein the agnathan antigen specific polypeptide comprises an N-terminal leucine rich repeat (LRRNT), one or more leucine rich repeats (LRRs), a C-terminal leucine rich repeat (LRRCT), and a connecting peptide, wherein the connecting peptide comprises an alpha helix b. transfecting a cell in culture medium with the cDNA clone of step (a) and c. isolating the agnathan antigen specific polypeptide from the culture medium.

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