Pyrazole derivatives and their use for the treatment of diseases relating to taars, such as depression, psychosis, parkinson&rsquos disease, adhd and diabetes

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

GALLEY GUIDO,NORCROSS ROGER,PFLIEGER PHILIPPE,GHELLAMALLAH CEDRIC

申请号：

NZ61735012

公开号：

NZ617350A

申请日:

2012.06.06

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided are pyrazole derivative compounds of general formula IA or IB, wherein the variables are as defined in the specification. Examples of the compounds include (S)-N-(4-(morpholin-2-yl)phenyl)-5-phenyl-1H -pyrazole-3-carboxamide hydrochloride and (S)-N-(4-(Morpholin-2-yl)phenyl)-1-(2-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride. The compounds are modulators of trace amine associated receptors (TAARs). The compounds may be useful in the treatment of metabolic or neurological disorders.

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中国工程科技知识中心

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