Pyrazole derivatives and their use for the treatment of diseases relating to taars, such as depression, psychosis, parkinson&rsquos disease, adhd and diabetes
Provided are pyrazole derivative compounds of general formula IA or IB, wherein the variables are as defined in the specification. Examples of the compounds include (S)-N-(4-(morpholin-2-yl)phenyl)-5-phenyl-1H -pyrazole-3-carboxamide hydrochloride and (S)-N-(4-(Morpholin-2-yl)phenyl)-1-(2-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride. The compounds are modulators of trace amine associated receptors (TAARs). The compounds may be useful in the treatment of metabolic or neurological disorders.