CHIMERIC ANTIGEN RECEPTORS FOR MELANOMA AND USES THEREOF

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专利权人:

发明人:

Jed J.W. Wiltzius,Stuart A. Sievers

申请号：

US15919408

公开号：

US20180280437A1

申请日:

2018.03.13

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to Chimeric Antigen Receptors (CARs) comprising antigen binding domains that specifically bind melanoma cells, polynucleotides encoding such CARs, and vectors comprising such polynucleotides. The present invention further relates to engineered cells comprising such polynucleotides and/or transduced with such viral vectors, and compositions including a plurality of engineered T cells. The present invention also relates to methods for manufacturing such engineered T cells and compositions and uses in treating a melanoma such engineered T cells and compositions.

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