COMPOSITIONS COMPRISING APTAMERS AND NUCLEIC ACID PAYLOADS AND METHODS OF USING THE SAME

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专利权人:

Children's National Medical Center

发明人:

Yang Liu,Pan Zheng,Toshihiko Tanno

申请号：

US16614505

公开号：

US20200171068A1

申请日:

2018.05.18

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The disclosure relates to compositions comprising a nucleic acid sequence having two domains: a cell targeting domain and a microRNA domain, wherein the cell targeting domain comprises an aptamer sequence that targets cancer cells and the microRNA domain comprises a microRNA sequence that binds to an endogenous mRNA sequence within a cancer cell and disrupts normal function of the cell.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/