ANDERSON, Christen M.;ARENA PHARMACEUTICALS; INC.;ARENA PHARMACEUTICALS, INC.;SHANAHAN, William R.
发明人:
ANDERSON, Christen M.,SHANAHAN, William R.
申请号：
USUS2011/049936
公开号：
WO2012/030939A1
申请日:
2011.08.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present disclosure relates to methods for weight management in an individual in need thereof by determining the level of renal sufficiency of the individual and prescribing or administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual, provided that the individual has a level of renal sufficiency selected from the group consisting of: no renal impairment, mild renal impairment, and moderate renal impairment. In addition, the disclosure relates to a method for selecting an individual for treatment with (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof from a plurality of individuals in need of weight management by determining the level of renal sufficiency of the individual and selecting the individual for treatment with (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof if the individual has a level of renal sufficiency selected from the group consisting of: no renal impairment, mild renal impairment, and moderate renal impairment.La présente invention concerne des procédés pour la gestion du poids d'un individu le nécessitant par la détermination du niveau de suffisance rénale de l'individu et prescription ou administration à l'individu d'une quantité thérapeutiquement efficace de (R)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1H-3-benzazépine ou d'un sel, solvate ou hydrate pharmaceutiquement acceptable de celle-ci, à condition que l'individu ait un niveau de suffisance rénale choisie dans le groupe consistant en : insuffisance rénale inexistante, insuffisance rénale légère et insuffisance rénale modérée. De plus, l'invention concerne un procédé de sélection d'un individu pour un traitement au moyen de (R)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1H-3-benzazépine ou d'un sel, solvate ou hydrat
