A remote patient monitoring system which is particularly well-suited for clinical out of center sleep testing (clinical OCST). Sensor nodes are grouped for wearing on the head, chest, and lower body of the patient. Sensor nodes wirelessly communicate sensor data to a nearby gateway, which communicates this data over a network (e.g., Internet) to one or more servers. The server(s) analyzes the sensor data for usage assurance, and to discern patient sleep patterns and characteristics. Guidance messages are generated by the system based on the analysis. Interfaces are provided to allow the patient to access their own information, and healthcare providers to access information collected regarding their patients.