The present invention relates to a compound capable of inducing endoplasmic reticulum stress, including at least a nanogold particle and a solvent. When the compound is treated to a chronic myelogenous leukemia patient, the endoplasmic reticulum stress of the human chronic myeloma leukemia cells can be induced, and the cells result in apoptosis and cell death, thus the chronic myeloma leukemia can be controlled and eased.本發明係一種能引發內質網壓力之組合物,其中,係至少包含奈米金及溶劑,當一慢性骨髓性白血病患者在攝入該能引發內質網壓力之組合物後,係可引發該慢性骨髓性白血病細胞之內質網壓力,造成細胞凋亡及壞死,進而緩合及控制慢性骨髓性白血病。