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AMELIORATION DU TRANSPORT DE MOLECULES THERAPEUTIQUES A TRAVERS LA BARRIERE HEMATO-ENCEPHALIQUE
专利权人:
BIOGEN IDEC MA INC.
发明人:
FARRINGTON, GRAHAM K.,SISK, WILLIAM
申请号:
CA2860579
公开号:
CA2860579A1
申请日:
2013.01.10
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The invention is based, at least in part, on the finding that a dimeric version of a BBB-transmigrating antibody (e.g., theTMEM30A (CDC-50A) binding antibody, FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 VHH. The invention provides, inter alia, molecules that increase transport of pharmacologically active agents across the blood brain barrier, methods for increasing transport across the blood brain barrier, and methods of treatment of disorders or diseases having a neurological component.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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