A MODIFIED EFFECTOR CELL (OR CHIMERIC RECEPTOR) FOR TREATING DISIALOGANGLIOSIDE Gp2-EXPRESSING NEOPLASIA

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专利权人:

发明人:

申请号：

EP12813454.1

公开号：

EP2771355A1

申请日:

2012.10.25

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

A modified effector cell includes a non-reversibly produced vector-encoded anti-GD2-BB-&zeta chimeric receptor for use in disialoganglioside GD2-expressing neoplasia, which is inserted in the cell, to obtain an effector cell that stably produces the anti-GD2-BB-&zeta chimeric receptor, the chimeric receptor having two distinct mutually fused portions, i.e. an intra-cytoplasmic portion and an extra-cytoplasmic portion.

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