Device for determining a value of non-invasive Blood glucose without finger to puncture the skin of a patient and without taking any blood Sample,That includes: - Two Laser sources for laser diode emitting respective, and operate these two Diode Laser sources in a frequency range between 500 and 1.000 nm, with power in the range between 0.01 and 100 MW - a sensor comprises photodiodes to receive the laser beam emitted by the laser diode and led to the photodiodes of the sensor a Centering system that CompRende Diaphragm is divided into four parts to accommodate a finger of a patient a Lever ready to open the Diaphragm is divided into four Parts and a Spring to close the diafragmDivided in to four Parts a Light Barrier arranged to control the start-up of two Diode Lasers in the finger of the patient a button to activate the deviceItivo and a screen, where, in Practice, the operation of said Device includes the following steps: the patient puts a finger in an Opening deviceWhile the lever is pulled to open the Diaphragm is divided into four Parts the release Lever, the Spring closes the Diaphragm, thus determining a provision focusing on the finger,Regardless of size,Within the focus of the Two Laser Beams emitted from the two laser diode and led to the photodiodes of the sensor the patient activates the device by pressing the Power Button,With the passage of the finger Shoots the Light barrier that controls the start-up of two Diode lasers and photodiodes of the read sensor values of the Two Laser BeamsResulting from Selective Absorption by the free Plasma Glucose and glycated hemoglobin present in the blood of the patient, lasers,Issued by the two lasers Diode and the device also comprises: a Processor a Stage prepared to forward these Analog values to the Processor which is proceedingFor, after the stabilisation of those two values, digitize, normalize and extract a large number of these two values, finding an average value, andThrough a particular algorithm, to ob