Paolo Lazzari;Gerard Aime Pinna;Ilaria Manca;Luca Pani;Giovanni Loriga;Stefania Ruiu
发明人:
Paolo Lazzari,Giovanni Loriga,Stefania Ruiu,Ilaria Manca,Luca Pani,Gerard Aime Pinna
申请号：
US12512818
公开号：
US08399457B2
申请日:
2009.07.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Nonane and decane diazabicyclic derivatives having homopiperazine as main ring, having affinity for the opioidergic μ and/or δ and/or k receptors and/or for all their receptorial subclasses, with central and/or peripheral activity, having formula (I), the isomeric forms and their mixtures included, wherein one or more atoms are in the corresponding isotopic forms:wherein: n is an integer equal to 1 or 2；one of the substituents R and R1 of the nitrogen atoms of the diazabicyclic ring is a —C(O)—RB group, wherein RB is a C1-C10 alkyl group, linear or branched when possible,the other remained substituent of R and R1 has the meanings reported in the description.
