Production of stable non-polyadenylated RNAs

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专利权人:

Massachusetts Institute of Technology

发明人:

Jeremy E. Wilusz,Phillip A. Sharp

申请号：

US14436228

公开号：

US09717749B2

申请日:

2013.10.16

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a 3′ terminal stabilizing triple helical structure. Related methods for expressing said RNAs in vivo and in vitro are also disclosed.

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