A kind of crystallization of I types and preparation method of the 2-maleate of tyrosine kinase inhibitor农业专利-农业学术服务平台

专利权人:: JIANGSU HENGRUI MEDICINE CO.; LTD.;JIANGSU HENGRUI MEDICINE CO., LTD.;江苏恒瑞医药股份有限公司;江蘇恆瑞醫藥股份有限公司

发明人:: SUN, Piaoyang,孙飘扬,孫飄揚,WU, Guaili,武乖利,YUAN, Bo,袁博,CHEN, Yongjiang,陈永江,陳永江

摘要：: Provide (R,E) the I types crystallization of-N- (4- (the chloro- 4- of 3- (pyridine -2- ylmethoxies) phenyl amino) -3- cyano -7- ethoxyquinoline -6- bases) -3- (1- methylpyrrole alkyl -2- bases) acrylamide 2-maleate (abbreviation SHR1258 2-maleates), preparation method, the pharmaceutical composition containing the crystal form. The SHR1258 2-maleates I types crystallization has good stability of crystal form and chemical stability, and the drug for treating disease related with EGFR receptor tyrosine kinases or HER-2 receptor tyrosine kinases can be prepared with what.提供了(R,E)-N-(4-(3-氯-4-(吡啶-2-基甲氧基)苯基氨基)-3-氰基-7-乙氧基喹啉-6-基)-3-(1-甲基吡咯烷基-2-基)丙烯酰胺二馬來酸鹽(簡稱SHR1258二馬來酸鹽)的I型結晶、其製備方法、含有該晶型的藥物組合物。所述SHR1258二馬來酸鹽I型結晶具有良好的晶型穩定性和化學穩定性，可用於製備治療與EGFR受體酪氨酸激酶或HER-2受體酪氨酸激酶有關的疾病的藥物。