According to an artificial bioparticle (1) characterized in that a leucine zipper (4) is integrated in each N terminal of an MVP (3) constituting a waist (8) of a vault (2) and a method of manufacturing an artificial bioparticle (1) in which a leucine zipper gene is integrated and expressed in a side to be an N terminal of an MVP gene, a novel artificial bioparticle including a vault of which large internal space can effectively be made use of, which can be used as a nanocapsule applicable to a drug delivery system (DDS), and a method of manufacturing the same are provided.藉由特徵為於構成穹窿體(2)之腰(8)之MVP(3)之N端分別納入白胺酸拉鏈(Leucine zipper)(4)之人工活體粒子(1)，及使白胺酸拉鏈基因納入成為MVP基因之N端之側，並使其表現之人工活體粒子(1)之製造方法，能獲得可應用在藥物遞輸系統(Drug Delivery System，DDS)等之奈米膠囊，並使用能有效利用其大的內部空間的穹窿體(vault)的新穎的人工活體粒子及其製造方法。
