Devices, methods and systems for predicting and detecting a change in a physiological condition of a subject are disclosed. A device for detecting and predicting a change in physiological condition of a subject may include one or more processors configured to: (i) analyze changes in a heart rhythm of a subject； (ii) analyze a signal from one or more biomarkers that are associated with a physiological condition of the subject； and (iii) determine, based on the changes in the heart rhythm and the signal from the one or more biomarkers, whether there is a change in the physiological condition of the subject during a time period.
