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HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
专利权人:
VERTEX PHARMACEUTICALS INCORPORATED
发明人:
STAMOS, DEAN,MARTINBOROUGH, ESTHER,NEUBERT, TIMOTHY,NUMA, MEHDI MICHEL DJAMEL,WHITNEY, TARA,ZIMMERMANN, NICOLE,HAMPTON, TARA LEANNE
申请号:
NZ58572908
公开号:
NZ585729A
申请日:
2008.11.12
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a compound of formula (I) where the substituents are as disclosed in the specification and examples of compounds of formula (I) are (S)-4-(3-( 6,7-dichloro-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide and (S)-4-(2-oxo-3-(7-( trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)yl)pyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating conditions such as arthritis, migraines, pain and epilepsy.
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