TOBIAS LINDA O.,SMITH ROSAMUND CAROL,HAN BOMIE,KIKLY KRISTINE KAY
申请号：
IN2581/KOLNP/2006
公开号：
IN254039B
申请日:
2006.09.08
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope fall within the scope of the invention and may be murine, chimeric, or humanized antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammals.
