DERIVES DE 2-PYRAZINONE DESTINES AU TRAITEMENT D'UNE MALADIE OU D'UN ETAT DANS LEQUEL L'INHIBITION DE L'ELASTASE NEUTROPHILE HUMAINE A UN EFFET BENEFIQUE

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专利权人:

ASTRAZENECA AB

发明人:

HANSEN, PETER,IVARSSON, MARIANNE,LAWITZ, KAROLINA,LONN, HANS,NIKITIDIS, ANTONIOS,RAY, ASIM

申请号：

CA2650553

公开号：

CA2650553C

申请日:

2007.05.07

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The invention provides compounds of formula (I) wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof； together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

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