A formulation comprising a plurality of multiparticulate minicapsules having solderless undiámetro of 0.5 mm to 5 mm, the minicapsules encapsulation medium containing Active ingredient and the minicapsules containing at least two different active ingredients, wherein the formulation seselecciona of: (a) formulations in which the minicapsules comprise a core which is a solution or suspensiónhidrófoba and containing at least one active ingredient, containing caplets one activosoluble ingredient in water and oil soluble active ingredient and (b) Formulations in which the minicapsules are formed from a core solution containing uningrediente active, and an encapsulating solution containing an active ingredient and forming, alestabilizarse, the encapsulation medium, wherein the active ingredient content solution encapsulaciónel same or different than the active core ingredient solution It can be obtained the caplets by a method selected from A) and B): A) a method wherein two different solutions, which do not dissolve each other or one another are disuelvendifícilmente, are contacted among them being solutions solution isa core a hydrophobic solution or suspension and a coating solution, and wherein a decubierta / core mixed suspension is processed through a die with a single hole and B) a process in which two different solutions, not with each other or one another are disuelvendifícilmente dissolved, are contacted among them, being solutions solution core isa hydrophobic solution and a cover and being selected formulation process lasminicápsulas of: (i) a method in which a core solution is ejected through an orifice and recoated solution is expelled through an outer hole for encapsulating the core solution, It is expelidadespués the resulting encapsulated sphere solution and cooling or hardening solution siendogelificada or solidified outer cover and (ii) a method in which a mixed suspension of sheath / core is processed through a boquillaque has a single hole.Una formul
