The present invention relates to new and improved interleukin-7 polypeptides,as well as compositions comprising the same, their preparation and uses. Theinvention more particularly relates to hyperglycosylated IL-7 polypeptideshaving improved properties, as well as their manufacture and therapeutic uses.The invention also discloses novel IL-7 polypeptides having modified aminoacid sequences containing artificially created glycosylation site(s), as wellas corresponding nucleic acid molecules, vectors and recombinant host cells.The invention also relates to the use of such polypeptides, cells or nucleicacids for curative or preventive treatment of mammalian subjects, includinghuman subjects.
