PROBLEM TO BE SOLVED: To provide a method for screening an inflammasome activation controlling material.SOLUTION: There is provided a method for screening an inflammasome activation controlling material which includes the step of bringing monocarboxylic acid into contact with polypeptide containing a lysine-rich arrangement of pyrin-domain and selecting monocarboxylic acid that combines with the lysine-rich arrangement, and a composition for controlling inflammasome activation, a medical product, food and drink, and an additive for animal feeding containing the obtained inflammasome activation controlling material.SELECTED DRAWING: None