Disclosed herein is a formulation for mitigating brain trauma including, in some embodiments, one or more ω-3 fatty acids, one or more curcuminoids, trans-resveratrol, α-glycerylphosphorylcholine (“α-GPC”), and uridine-5′-monophosphate (“UMP”). The formulation is an oil-based emulsion including the one or more ω-3 fatty acids, the one or more curcuminoids, the trans-resveratrol, the α-GPC, and the UMP for oral administration. Also disclosed herein is a packaged formulation for mitigating brain trauma including, in some embodiments, a sealed pouch containing a single dose of the oil-based emulsion including the one or more ω-3 fatty acids, the one or more curcuminoids, trans-resveratrol, α-GPC, and UMP. Also disclosed herein is a method for mitigating brain trauma including, in some embodiments, administering the formulation before participating in an activity having an increased incidence of brain trauma, after participating in an activity having an increased incidence of brain trauma, or after sustaining brain trauma.