Thurecht, Kristofer,Howard, Christopher,Mahler, Stephen
申请号：
AU2016214978
公开号：
AU2016214978A1
申请日:
2016.02.05
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Disclosed are targeting constructs for targeting a target site, including a molecule or complex of interest. The targeting constructs comprise a polymer chain and a plurality of multi-specific molecules each of which includes an affinity moiety for binding with the polymer chain and a targeting ligand for binding with the target site. The polymer chain may be associated with a therapeutic or diagnostic agent and generally comprises a plurality of sites, wherein individual sites bind with a multi-specific molecule of the target construct. The present disclosure also relates to methods of preparing the targeting construct and to its use in therapeutic and diagnostic applications.
