A biopsy system includes a biopsy targeting assembly, a needle, and a biopsy device. The biopsy targeting assembly includes a cradle. The needle is releasably supported by the targeting assembly. The biopsy device includes a body having a tissue collection assembly and a cutter. The cutter is translatable relative to the body and extends distally from the body. The cradle of the targeting assembly releasably supports the body of the biopsy device distally of the tissue collection assembly. The biopsy device translates a distal portion of the cutter within the needle with the needle supported by the targeting assembly.
