This invention provides methods for inducing an immune response against a Her-2/neu antigen-expressing tumor and for treating the same and vaccinating against the same in human and canine subjects using a combination of radiation therapy and a recombinant attenuated Listeria strain vaccine.本發明提供用於誘導針對Her-2/neu抗原表現性腫瘤之免疫反應的方法以及用於在人類及犬類個體中使用放射療法與重組減毒李斯特菌屬菌株疫苗之組合來治療該腫瘤及針對該腫瘤進行疫苗接種的方法。